The various glycoproteins in the mucosa, obtained from 25 patients with chronic maxillary-sinusitis, were observed histochmically by means of Jones and Reid technique.
The purposes of the study are to know the distribution of various glycoproteins in mucosa of each pathological type(edematous, infilterative, fibrous, and mixed) and to find any clues to explain the pathogenesis of chronic maxillary sinusitis.
@ES The results were as follows:
1. The order of frequency in various pathological types were edematous type(44.0%), mixed type(32.0%), infiltrative type(12.0%) and fibrous type(12.0%).
2. Distribution of glycoproteins in mucosa.
1) In the colummer cell:
i) Acid glycoprotein was demonstrated in 76.0% of the cases, which was composed of sulfomucin(78.9%) and sialomuchin(21.1%), and neutral glycoprotein was in 24.0%.
ii) relation between various glycoproteins and pathological types.
a. Neutral glycoprotein was observed in mixed type(37.5%) and edematous type(27.3%).
b. Among the acid glycoproteins, sialidase sensitive sialomucin was found in infiltrative type(33.3%) and in edematous type(14.2%), while sialidase resistant sialomucn was in edematous(14.2%) and mixed type(20.0%).
2) In the goblet cell:
Sulfomucin was only demonstrated.
3) In the basement membrane:
i) Acid glycoprotein was observed in 96.6% of cases, which was composed of sulfomucin (91.7%) and sialidase resistant sialomucin(8.3%), while neutral glycoprotein was only in 4.0%.
ii) Neutral glycoprotein was observed in mixed type(12.5%) and sialidase resis tant sialomucin was in edematous type(18.2%).
3. Distribution of various glycoproteins in submucosa.
1) In the submucosal stroma:
Sulfomucin was only observed.
2) In the gland:
The subepithelial glands were mixed964.0%), serous(28.0%) and mucous glands(8.0%).
Glycoproteins in the glands were sulfomucin of acid type(43.9%) and neutral type(56.1%).
3) Around blood bessel:
Glycoprotein was acid type, consisted of sulfomucin(92.0%) and sialidase resistant sialomucin(8.0%). Sialidase resistant sialomuchin was only found in the edematous type(18.1%).
As the result of this study, acid glycoprotein, especially sulfomucin was more predominant than other types in all tissue of the mucosa of chronic maxillary sinusitis except in the subepithelial gland. It should be studied further to find out the
mechanism of acid glycoprotein in chronic maxillary sinusitis.
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